Article Details : |
| | Article Name : | | The effect of dietary methionine restriction and the
mechanism of glucose and lipid metabolism in
obese induced C57BL/6 Mice | Author Name : | | MARIAMA MAMIE LAHAI
WANG YANAN
ZHANG JIAHONG
GUO HAITAO
GUOWEI LE1 | Publisher : | | Bridge Center | Article URL : | | | Abstract : | | Background: In animal study, dietary supplementation of
methionine (Met), depending on dosage is beneficial for improving
several metabolic health problems, such as obesity, diabetes and
cardiovascular disease which potential benefit was investigated on
cardiac function in glucose and lipid metabolism. Therefore, in order
to effectively complete this work, the following parameters were
examined: Growth performance (Weight), fasting blood glucose levels,
measurement of malondialdehyde, total antioxidant capacity levels, Creactive protein and Non-esterified Fatty Acids.
Methods: In this study, 42 male C57BL/6 mice were
randomly shared into three groups of 18 each and fed a diet comprises
of Control (Con) group given 4% fat, 0.86% Met and 67.17 % starch.
High Fat + High Met (HF+HM) group 20% fat, 0.86% Met and 51.17% starch. While High Fat + Low Met (HF+LM) received 20% fat, 0.17%
Met and 51.17% starch respectively.
Result: Met restriction (MetR) showed decreases in body
weight gain followed by reduction in fasting blood glucose levels
observed throughout the study in both Con and MetR groups. However,
noticeable reduction in total antioxidant capacity (T- OAC) was
observed in the HM group, but Malondialdehyde (MDA) levels were
higher (?0.05) in HM than Con and MetR group suggesting oxidative
stress damage. However, changes were observed in Non-Esterified
Fatty Acids (NEFA) parameters in the three study groups, though not
statistically significant. There was an increase in C- Reactive Protein
(CRP) activity of HF+HM fed mice, which was indicative of
inflammation, although not specific but found to correlate with risk of
cardiovascular disease.
Conclusion: Dietary MetR is effective in regulating weight
gain, glucose and lipid homeostasis and restoring oxidative damage
during Oxidative stress situations through adaptive changes. | Keywords : | | Dietary Methionine Restriction, Oxidative Stress,
Reactive Oxygen Species, Cardiovascular Disease, Essential Amino
Acids |
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