Article Details : |
| | Article Name : | | Frequency of PTEN gene Mutation in Oral
Squamous cell Carcinoma | Author Name : | | MOHMMAD AWAD GINAOI, HUSSAIN GADELKARIM AHMED
IBRAHIM ABDELMAGEED GINAWI, MOHAMMED S. ALSHAMMARI | Publisher : | | Bridge Center | Article URL : | | | Abstract : | | Objective: The aim of this study was to screen for the
mutation in PTEN gene among Sudanese patients with oral cancer by
Molecular and Immunohistochemical techniques and to identify the
frequency of oral cancer patients with PTEN gene Methods: One
hundred Formalin fixed paraffin processed tissue blocks from patients
previously diagnosed as having oral cancer with their related data
retrieved from different histopathology laboratories in Khartoum City.
Results: Of the 100 patients with Oral Squamous Cell Carcinomas
(OSCCs), 30 (30%) were found with Loss of PTEN expression by
Immunohistochemical methods. Out of 30 negative patients, 23 were
males and the 7 were females. Exon 9 of PTEN gene was successfully
recombined in all 100 patients samples. Conclusion: The findings of
the present study suggest the role of PTEN gene mutation in the
etiology of oral cancers in Sudan. Further studies with involving more
exons for PTEN gene are required.
| Keywords : | | PTEN gene mutation, Oral Squamous cell Carcinoma |
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