European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Frequency of PTEN gene Mutation in Oral Squamous cell Carcinoma
Author Name :
MOHMMAD AWAD GINAOI, HUSSAIN GADELKARIM AHMED IBRAHIM ABDELMAGEED GINAWI, MOHAMMED S. ALSHAMMARI
Publisher :
Bridge Center
Article URL :
Abstract :
Objective: The aim of this study was to screen for the mutation in PTEN gene among Sudanese patients with oral cancer by Molecular and Immunohistochemical techniques and to identify the frequency of oral cancer patients with PTEN gene Methods: One hundred Formalin fixed paraffin processed tissue blocks from patients previously diagnosed as having oral cancer with their related data retrieved from different histopathology laboratories in Khartoum City. Results: Of the 100 patients with Oral Squamous Cell Carcinomas (OSCCs), 30 (30%) were found with Loss of PTEN expression by Immunohistochemical methods. Out of 30 negative patients, 23 were males and the 7 were females. Exon 9 of PTEN gene was successfully recombined in all 100 patients samples. Conclusion: The findings of the present study suggest the role of PTEN gene mutation in the etiology of oral cancers in Sudan. Further studies with involving more exons for PTEN gene are required.
Keywords :
PTEN gene mutation, Oral Squamous cell Carcinoma

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