European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Attenuation of fluoride-induced nephrotoxicity in rats by leaf extract of punarnava ( Boerhaavia diffusa L.)
Author Name :
Shashi A, Jawant Kaur
Publisher :
Bridge Center
Article URL :
Abstract :
The present study investigated the toxic effects evaluated as histopathological changes of sodium fluoride in kidney of rats. Wistar albino rats were divided into eight groups. Group I received 1ml deionized water /kg b.w. / day orally daily by a gastric tube for 40 days. The control and experimental animals were sacrificed and the kidney tissue. Group II were orally administered with 300 ppm of NaF for 40 days were, pre and post-treated with 500ppm /kg b.w. /day + 300 ppm NaF /kg /b.w /day of leaf extract of Boerhaavia diffusa L. for 20 days respectively. Group III were orally administered with 600 ppm of NaF for 40 days were, pre and post-treated with 500 ppm /kg b.w. /day + 600 ppm NaF /kg /b.w /day of leaf extract of Boerhaavia diffusa L. for 20 days respectively Group IV positive control were administrated with 500 ppm /kg b.w. / day of leaf extract of Boerhaavia diffusa L. for 20 days. processed for histopathological examination. Fluoride caused degenerative changes in the renal glomeruli and tubules.There was renal tubular necrosis, dilation of proximal and distal tubules, vacuoles formation, sloughing of the tubular epithelial cells, and cloudy swellings, and the glomerular degeneration along with alterations in glomerular size, proliferation of mesangial cells, marked lobulation, hypertrophy, atrophy or shrinkage with expanded Bowman’s capsule were visible. These changes were reduced in the recovery group but not returned to normal. The findings implied that leaf extract of Boerhaavia diffusa L. can be used as an effective protecting agent against sodium fluoride induced nephrotoxicity.
Keywords :
Albino rats, Boerhaavia diffusa L., Nephrotoxicity, pathological changes, Sodium fluoride.

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