| Article Details : |
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| | | Article Name : | | | Immunohistochemical evaluation of laminin
expression in breast cancer among Sudanese
women in Khartoum state, Sudan 2017 | | Author Name : | | | SAFWA ABDELGADIR ABDALLAH, Dr. AGEEB MOHAMMED HASSAN, HELME IBRAHIM ABDALLATIF ALI | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Background: Cancers are heterogeneous tissues comprised of
multiple components, including tumor cells and microenvironment
cells. Laminin is a glycoprotein with diverse functions in
carcinogenesis including cell proliferation, invasion, metastases and
epithelial-mesenchymal transition (EMT). In breast cancer (BC)
laminin expression is speculated to be associated with unfavorable
clinicopathological and molecular characteristics.
Method: This descriptive, cross sectional study was performed
to Evaluate laminin expression in breast cancer among Sudanese
women, in This Cross sectional study which conducted at Radiation
isotopes center of Khartoum (RICK) in Khartoum (Sudan) from
December 2016 to April 2017.we aimed to evaluate the
immunohistochemical expression of laminin tumor marker in breast
cancer patients. Fourty Samples of formalin fixed wax embedded
blocks were selected and sectioned and immunohistochemically stained
to evaluate laminin expression. Results: Out of 40 patients with Breast cancer, most
participants were in age group between 40-50 years, four cases (22%) at
age 40-50 were positive for laminin expression, while fourteen (78%)
were negative & according to the distribution of receptor status five
cases (27.5%), four cases (22%) of triple negative TN and not triple
negative were positive respectively. most of positive expression were
associated with Grade I while most of negative with Grade II.
Conclusions: The laminin expression results were
insignificantly correlated with Age, grade, diagnosis and receptor
status, further studies including large number of participants
required. | | Keywords : | | | Breast cancer, laminin, Sudan, Immunohistochemistery |
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