European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Diagnostic Value of Serum Osteopotin in Ovarian Cancer Patients
Author Name :
RIMAZ ALHAG GURASHI1, Prof. MOAWIA E. HUMMEIDA2, F. G. ABDELAZIZ
Publisher :
Bridge Center
Article URL :
Abstract :
Amongst all gynecological cancers, ovarian cancer is the most lethal malignancy worldwide, aggressive local invasion and the lack of sensitive early screening methods, poses the most difficult in early diagnosis, furthermore, its high mortality rate has made it one of the most investigated fields in gynecological oncology during this year in USA. The aim of the study is to assess the level of serum biomarker osteopontin (OPN), among ovarian cancer women at Khartoum State - Sudan. and compare the findings of osteopontin (OPN) serum concentration with the control group, and correlate with study variables. Then estimate the predictive values of this marker. Osteopontin testing were performed to all serum samples to determine the concentrations by enzyme linked immunosorbent assay for quantitative determination of osteopontin. By the end of this study, concludes that epithelial ovarian cancer is the most common followed by germ cell tumors. Serum level of osteopontin biomarker within the reference range in the control group. In contrast, increasing serum level in the ovarian cancer patients, a general agreement that a combination of osteopontin may increase diagnostic sensitivity and specificity when combined with the golden markers cancer antigen 125.
Keywords :
ovarian cancer, biomarker, osteopontin, epithelial OV
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