European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Assessment of the relationship between thyroid diseases involvement and effect on hemostasis; a prospective analysis of hemostasis profiles in women with control group in Saudi Arabia
Author Name :
BASMA AWNI AL FARRAH1, Dr. NADIA MADANI M. AHMED2, Dr. TARIG A. M. HAMID3
Publisher :
Bridge Center
Article URL :
Abstract :
As it has been well documented that bleeding or coagulations disorders are common and especially in patients with thyroid disease, we conducted this case control study covered 153 study participants whom divided into two study groups; the first group who diagnosed with thyroid gland abnormalities (cases group) and healthy group (control group). Blood samples for Thyroid Function Tests and Hemostasis and coagulations investigations were carried out. All participants were selected under informed consent and especially for the control group otherwise healthy (18). However all cases were know by physicians as patients with thyroid diseases. Investigation of coagulation and bleeding disorders in relation to thyroid is a hot topic, but requires intensive research. The study was aimed to study of coagulation parameters among ladies with hypo and hyper thyroid diseases in Saudi Arabia and to investigate the role of Stago Coagulation analyzer for assessment of abnormal hemostasis in thyroid diseases, to estimate abnormal hematological findings in women with hypo thyroid diseases or thyroidectomy patients as well as hyperthyroid patients. We used the following techniques including, Complete Blood Count and coagulation parameters sucha as Prothrombin Time (PTT) / Fibrinogen/Activated Partial Thromboplastin Time (APTT), Platelets Count using Stago cogulation analyzer while for the thyroid function using the VIDAS® for Thyroid Stimulating Hormone (TSH), FT4 and FT3 assays. All participants were females at Alsamrya Medical Complex in Jeddah, Saudi Arabia, from December 2017 until July 2019. Participants age range from 16 to 50 years with average age 35 years and 12 to 54 years average 30.9 years for cases and the control age group respectively. Nearly two thirds of them were classified in cases group (66%) while (34%) were in the control group as displayed in table 1 and figure 1. All participants were females at Alsamrya Medical Complex in Jeddah, Saudi Arabia, from December 2017 until July 2019. Participants age range from 16 to 50 years with average age 35 years and 12 to 54 years average 30.9 years for cases and the control age group respectively. We found a significant increasing in bleeding time (difference of 0.5 seconds, p value 0.002), clotting time (difference of 0.7 seconds, p value < 0.001), PT (difference of 0.6 seconds, p value 0.001), and APTT (difference of 0.2 seconds, p value 0.046) and the result in platelets count (difference of 8.9 x103, p value 0.506) and fibrinogen level (difference of 0.8 (mg/dl), p value 0.830) between the two study groups. In conclusion, our study is one of very rare studies and our result showed excellent and extreme significant compared to literature. We were able to link effects on coagulation factors synthesis or on platelet function and metabolism, fibrinolytic system with support of advance understanding of the mechanism of action of thyroid hormone at the cellular level and may provide insight into the functioning and regulation of the hemostatic system itself therefore we recommend that these test should be included routinely for any patients with thyroid disease especially those undergoing surgery.
Keywords :
Thyroid, coagulation abnormalities, bleeding, clotting, hypothyroidism, hyperthyroidism, thrombosis
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