| Article Details : |
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| | | Article Name : | | | Eugenia punicifolia leaf extract has a hypotensive
effect and inhibits angiotensin-converting
enzyme activity in both in vitro and in vivo models | | Author Name : | | | DENISE MORAIS LOPES GALENO1, OZANILDO VILAÇA DO NASCIMENTO2, MAÍRA SOARES BIVÁQUA DE ARAÚJO3, TATIANE PEREIRA DE SOUZA4, EMERSON LIMA SILVA5, ROSANY PICCOLOTTO CARVALHO6, FERNANDO VILLALAZ CHIONG NETO7, RAPHAEL HOLANDA SANTOS8, ZINALTON GOMES DE ANDRADE9, JOSÉ WILSON DO NASCIMENTO CORRÊA10, FELIPE MOURA ARAÚJO DA SILVA11, HECTOR HENRIQUE FERREIRA KOOLEN12, CARLOS CLEOMIR PINHEIRO13, FRANCISCO CÉLIO MAIA CHAVES14 | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Background: Chronic high blood pressure has for many years
been considered a public health problem. Eugenia punicifolia is a
plant used to treat diabetes by the local population, however its
hypotensive effect has never been investigated.
Materials and methods:The effect of the 21-day treatment on
systolic blood pressure was measured using the two kidneys, one clip
(2K1C) model with hypertensive Goldblatt rats, which were treated
with a repeated dose of 0.30 g/kg/day of extract by gavage (EEP group
300) and 0.15 g/kg/day (EEP group 150). Prior to pharmacological
testing, acute toxicity tests were also performed on the rats. The activity
of plasma angiotensin converting enzyme (ACE) during the experiment
was determined spectrofluorometrically.
Results: The EEP, in concentrated form, inhibited ACE
activity and a hypotensive effect in vivo. Systolic blood pressure (SBP)
levels were significantly reduced in the EEP 150 and EEP 300 groups,
respectively. ACE activity was inhibited in plasma.
Conclusion: Eugenia punicifolia appears to affect blood
pressure significantly. Hypotension produced by the EEP extract can
be related to the inhibition of ACE. | | Keywords : | | | Angiotensin converting enzyme; Hypotension; Eugenia
punicifolia leaves, Antihypertensive |
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