| Article Details : |
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| | | Article Name : | | | Ensaios Pré-clínicos Toxicológicos:
Uma Revisão sobre Métodos alternativos para
substituição do uso de cobaias
| | Author Name : | | | CRISTINA COMAPA RABELO, JOICIANE PAES DE CARVALHO, VANESSA DE OLIVEIRA CAMPOS, CLAUDIA DANTAS COMANDOLLI-WYREPKOWSKI, BRUNO BEZERRA JENSEN1 | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | There is a record of the use of guinea pigs since antiquity, with
the aim of studying reactions caused by different substances in a living
organism. Through the field of innovation of science, today we have
alternative means that replace the use of these guinea pigs. This
substitution is being made gradually and it is always necessary to
validate the tests performed, so that in the future the guinea pigs are no
longer used in these studies. This article is an integrative literature
review, which aims to discuss methods that are an alternative to the use
of guinea pigs in toxicological experiments and to evaluate their
advantages and disadvantages. The methodology used was to perform a database search for scientific articles published in indexed journals,
selected through database searches: Scientific Eletronic Library Online
(SciELO), PubMed and ScienceDirect. 394 scientific articles were found
and based on the inclusion and exclusion criteria, only 06 were used for
this study. Through the evaluated works, we concluded that the
alternative methods that substitute the use of guinea pigs, have several
advantages in their handling. However, these methods cannot replace
all the tests, and the use of animals is still necessary. | | Keywords : | | | Scientific experiments, Guinea pigs, Alternative methods. |
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