| Article Details : |
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| | | Article Name : | | | Anti-diabetic and hypolipidemic effects of raw quail (Coturnix japonica) eggs on alloxan induced diabetic rats | | Author Name : | | | Fatima Wakili Farouk | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | This study evaluates the anti-diabetic activity Quail egg in an alloxan induced hyperglycaemia in rats, using chlorpropamide as a standard oral anti-diabetic drug. The anti-diabetic effect was evaluated using 60 rats, splatted to 5 groups of 12 rats, consisting of normal control, diabetic rats treated with Quail egg, diabetic control rats, chlorpropamide treated rats (84mg/kg) and normal rats treated with Quail egg, once daily, orally. Diabetes was induced using 100mg/kg body weight of alloxan. The pancreas was examined histopathologically. The serum level of glucose of the rats was evaluated after 24 hours, to confirm diabetes induction, with subsequent treatment with quail egg and chlorpropamide, for 49 days. Serum glucose and lipid profile (cholesterol, triglycerides, LDL and HDL), were determined after the 49th dose of treatment with quail egg and chlorpropamide. Following treatment with quail egg and chlorpropamide, once daily, for 49 days, a significant hypoglycemic and hypolipidemic effect was observed as evident from lower serum levels of the glucose and lipid profile, when compared to diabetic control group. Nonetheless, significant higher (P<0.05) mean serum level of glucose as well as lipid profile were observed in diabetic rats treated with Quail egg than in normal control. Histopathological examination of pancreas of diabetic rats treated with the quail egg shows low percentage regeneration of ?-cells. It can be concluded that Quail egg has low antidiabetic and hypolipidemic effects and may therefore not confer benefit when used as a single antidiabetic agent. | | Keywords : | | | Diabetes, Quail egg, Blood sugar, Lipid profile |
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