European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
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Article Details :
Article Name :
A compact immune-transcript score (CD3E?, IL10?) improves severity classification in pediatric iron-deficiency anemia beyond BRINDA-adjusted ferritin, Ret-He, and hepcidin
Author Name :
Momena Sami Ahmed Mohammed, Prof. Nadia Madani Mohamed Ahmed, Dr. Tarig A. M. Hamid, Dr. Shireen Shereen Mahy Aldin Abdallah, Dr. Mutaz Mohamed Ibrahim Ali
Publisher :
Bridge Center
Article URL :
Abstract :
Background: Iron-deficiency anemia (IDA) remains the leading cause of childhood anemia worldwide and is particularly common in infection-prone low- and middle-income regions where inflammation complicates biomarker interpretation. Ferritin, the traditional marker of iron stores, is an acute-phase reactant and thus confounded by inflammatory signals. The WHO and BRINDA initiatives recommend inflammation-adjusted ferritin interpretation, while functional indices such as reticulocyte hemoglobin equivalent (Ret-He) and regulatory markers like hepcidin provide additional insight into iron supply and metabolic control. However, these parameters overlook the immune
Keywords :
Iron-deficiency anemia, child, BRINDA, hepcidin, Ret-He, RT-qPCR, dried blood spot, CD3E, IL10.
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