| Article Details : |
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| | | Article Name : | | | Coagulation profile (Prothrombin Time, Activated
Partial Thromboplastin Time, D-dimer) in Chronic
Lymphocytic Leukemia in Sudanese patients | | Author Name : | | | DUAA MOHY ALDEEN MOHAMMED M.A., Dr. AMIRA AHMED K. HUMEIDA | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Background: chronic lymphocytic leukemias are a
heterogeneous group of conditions characterized by an increased
number of small, mature appearing lymphocytes in the blood.
Haemostasis disorders are complications of chronic lymphocytic
leukemia which could be diagnosed by coagulation profile (D-dimer,
PT and APTT).
Objective: The purpose of this study was to evaluate the
haemostatic property among chronic lymphocytic leukemia patients in
Sudan by determining D-dimer level, prothrombin time (PT) and
activated partial thromboplastin time (APTT).
Materials and Methods: 50 cases were included in this study
with Chronic Lymphocytic Leukemia and 25 individuals as control
group, All of them were Sudanese, we evaluated to determine D-dimer
was measured using VEDALAB EASY READER, PT and APTT were
measured by semi automated coagulometer, among in the two group.
Result: The result of the patients D-dimer level mean
was565.96±474.22ng/ml and control mean was102.44±33.86ng/ml (pvalue0.000),patients PT mean was 15.14±9.16 second and control group mean was12.20±1.68 second (p-value 0.032), and mean APTT
for patients was53.86±27.95 second and control group was 31.44±8.09
second (p-value0.000).
Conclusion: Our study confirms the hypercoagulable state
among chronic lymphocytic leukemia in Sudan, which has been
determined by elevated D-dimer, PT and APTT. | | Keywords : | | | D-dimer level, Chronic lymphocytic leukemia, Sudan |
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