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| | | Article Name : | | | Serotonin is a useful non-invasive marker in diagnosis of gastroeosophageal varices in HCV cirrhotic patients | | Author Name : | | | Inas Elkhedr Mohamed, Mohamed Lotfy, Eman Mahmoud Ezzat | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Oesophageal varices considered a serious consequence of portal hypertension, Serotonin is known as 5-hydroxytryptamine (5-HT) may contribute to maintaining portal hypertension in patients with cirrhosis. Aim of the work: To evaluate the validity of plasma serotonin concentration as a predictor of the presence of esophageal and/or gastric varices in HCV related cirrhosis. Materials and Methods: 100 HCV cirrhotic patients 50 of them with gastroesophageal varices and 50 without, 25 healthy volunteers served as control. All participants were subjected to Lab investigations( CBC, AST & ALT,PT, INR, T and D Bilirubin, a-Fetoprotein, Serum albumin, hepatitis HCV Ab, HBV sAg, HCV RNA, urea and serum creatinine). Child and MELD scores were calculated, upper GI endoscopy for patients, and serum serotonin levels were measured. Results: among 78 were males (78.00%) and 22 were females (22.00%). Among the twenty five healthy volunteers 8 females (32%) &17 males (68%). Mean age for patients was 53.06±7.55while mean age for control group was 41.15±8.18. 38 (76%) of patients were Child A and 12 (24%) were Child B. Ten patients had gastric varices upon endoscopy (20%), eight patients (16%) had Grade I esophageal varices, 25 patients (50%) with Grade II, while 18 of them (36%) with Grade III. Patients with varices had higher plasma serotonin level (p-value <0.001). patients with fundal varices had higher plasma serotonin (p-value = 0.02). increased serotonin in those who had grade III varices (p=0.007). (ROC) curve was used to define the best cut off value of the serotonin plasma level which was >30 (ng/ml) with sensitivity of 95%, specificity of 100%, positive predictive value of 100%, negative predictive value of 90.9% with diagnostic accuracy of 98.7%. In conclusion: the high levels of plasma serotonin in HCV cirrhotic patients with portal hypertension and developed varices (specifically fundal varices); may consider serotonin is a useful non-invasive marker for diagnosis and follow up gastroesophageal varices. | | Keywords : | | | Serotonin, non-invasive marker, diagnosis of gastroeosophageal varices, HCV cirrhotic patients |
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