| Article Details : |
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| | | Article Name : | | | Serotonin is a useful non-invasive marker in
diagnosis of gastroeosophageal varices in HCV
cirrhotic patients | | Author Name : | | | INAS ELKHEDR MOHAMED1
MOHAMED LOTFY, EMAN MAHMOUD EZZAT | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Oesophageal varices considered a serious consequence of portal
hypertension, Serotonin is known as 5-hydroxytryptamine (5-HT) may
contribute to maintaining portal hypertension in patients with
cirrhosis. Aim of the work: To evaluate the validity of plasma serotonin
concentration as a predictor of the presence of esophageal and/or
gastric varices in HCV related cirrhosis. Materials and Methods: 100
HCV cirrhotic patients 50 of them with gastroesophageal varices and
50 without, 25 healthy volunteers served as control. All participants
were subjected to Lab investigations( CBC, AST & ALT,PT, INR, T
and D Bilirubin, ?-Fetoprotein, Serum albumin, hepatitis HCV Ab,
HBV sAg, HCV RNA, urea and serum creatinine). Child and MELD
scores were calculated, upper GI endoscopy for patients, and serum
serotonin levels were measured. Results: among 78 were males
(78.00%) and 22 were females (22.00%). Among the twenty five healthy
volunteers 8 females (32%) &17 males (68%). Mean age for patients
was 53.06±7.55while mean age for control group was 41.15±8.18. 38
(76%) of patients were Child A and 12 (24%) were Child B. Ten
patients had gastric varices upon endoscopy (20%), eight patients
(16%) had Grade I esophageal varices, 25 patients (50%) with Grade II, while 18 of them (36%) with Grade III. Patients with varices had
higher plasma serotonin level (p-value <0.001). patients with fundal
varices had higher plasma serotonin (p-value = 0.02). increased
serotonin in those who had grade III varices (p=0.007). (ROC) curve
was used to define the best cut off value of the serotonin plasma level
which was >30 (ng/ml) with sensitivity of 95%, specificity of 100%,
positive predictive value of 100%, negative predictive value of 90.9%
with diagnostic accuracy of 98.7%. In conclusion: the high levels of
plasma serotonin in HCV cirrhotic patients with portal hypertension
and developed varices (specifically fundal varices); may consider
serotonin is a useful non-invasive marker for diagnosis and follow up
gastroesophageal varices. | | Keywords : | | | Serotonin, non-invasive marker, diagnosis of
gastroeosophageal varices, HCV cirrhotic patients |
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