European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Neurobehavioural dysfunction in experimental fluorosis
Author Name :
SHASHI A. 1 JATINDER KUMAR
Publisher :
Bridge Center
Article URL :
Abstract :
To assess the toxic effect of sodium fluoride on neurobehavior the present study was performed. Young and healthy Wistar albino rats weighing 100-200 g were randomly grouped in four separate cages. Group I was given 1 ml double distilled deionized water/kg body weight/day for forty days and kept as control. The remaining groups II, III and IV were treated with 100, 200 and 300 ppm of sodium fluoride/kg body weight/day via oral gavage for the same period. After treatment period rats were assessed for behavioral parameters exploratory and non-exploratory motor activity by open field habituation test. A significant (p<0.05) influence on exploratory motor activity assessed on sodium fluoride administered to rats was noted on first occurrence to the open field test. The rats exposed to different sodium fluoride concentrations demonstrated a significant (p<0.05) difference in anxiogenic profile of behavioral changes, as measured by time spent freezing and vegetative behaviors. There was a significant(p<0.05) session factor diminishing effect due to habituation over the course of three successive test sessions in open field test.
Keywords :
Neurobehavioral toxicity, Open field test, Sodium fluoride, Wistar albino rats
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