| Article Details : |
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| | | Article Name : | | | Fibrinolytic Alteration among Sudanese Patients
with Hypertensive Type 2 Diabetic Mellitus patients | | Author Name : | | | ADIL ABD RHMAN EISSA AHMED, FATH ELRHMAN M. H. GAMEEL, AMAR MOHAMED ISMAIL | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Background: Diabetes mellitus and hypertension are
complexes diseases result from inter reaction of different of
predisposing factors.
Aim: to assess levels of Fibrinogen, D-Dimer and Fibrin
Degradation Products in Sudanese with Hypertensive type 2 Diabetic
mellitus patients.
Methods: Case control study, a total of 400 subjects classified
to 300 Sudanese with hypertensive type 2 diabetic mellitus as patients
and 100 healthy individual as control group, age range between 30
and 90 years. Fibrinogen was assessed by coagulometer, D-Dimer and
Fibrin Degradation Products measured by ELISA.
Results: Significant increase between Fibrinogen, D-dimer
and fibrin degradation Products levels according to study compared to
control groups (p-value = 0.000). There were Significant decrease
between Fibrinogen, D-dimer and fibrin degradation Products levels
according to neuropathy in population study (p-value =0.012, 0.008
and 0.0.005) respectively. Significant increase in Fibrinogen and Ddimer of nephropathy in case study (p-value=0.021). There were
significant decrease Fibrinogen and D-dimer in retinopathy in case group (p-value=0.049 and 0.004) respectively. Fibrinogen, D-dimer
were significantly increase between age groups (p-value =0.00 and
0.010) respectively.
Conclusions: There are most increase in parameters of
fibrinogen, D-dimer and FDPs of patients and others demographic
data and thus recommended used to monitor a complications. | | Keywords : | | | Type 2 diabetic hypertensive patients, Fibrinogen, Ddimer Fibrin Degradation Products. |
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