European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Natural Phytochemicals Induces Apoptosis in Cervical Cancer Cell Line: A Comparative Preliminary Study
Author Name :
MOHAMMAD AZHAR IMRAN, ABBAS ALI MAHDI, NAJMUL ISLAM1
Publisher :
Bridge Center
Article URL :
Abstract :
Cervical malignancy is the most common female cancer around the world, and it remains a challenge to manage pre-invasive and invasive injuries. There is an incredible requirement for agents capable of inhibiting cervical cancer. Here, we report that various phytochemicals and natural compounds like Lycopene, Rutin, Quercetin, Tangeritin, Proanthocyanidins and Beta-carotene which are a dietary phyto-compound possess potentially important anticancer effects. Caski cell line was separately co-cultured for 24 hr (0-50 ug/ml) with Lycopene, Rutin, Quercetin, Tangeritin, Proanthocyanidins and Beta-carotene. Cell proliferation was measured by MTT assays. The transcendent method of cell death in Caski cell lines was apoptosis, as showed by caspase-9, - 3 activation by caspase activity assay. The results of this study revealed that Lycopene, Rutin, Quercetin, Tangeritin, Proanthocyanidins and Beta-carotene were potential inhibitors of cervical cancer cell growth.
Keywords :
Cervical Cancer, Reactive Oxygen species, Z-LEHDFMK, Z-DEVD-FMK
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