| Article Details : |
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| | | Article Name : | | | Study to the effect of Thyroid Dysfunction on Lipid
Profile | | Author Name : | | | DHEYAA SH. HAMMAD | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | This study was carried out to investigate the pattern of lipid
profile in individuals with thyroid dysfunction and healthy control
and to know whether any correlation exists between serum lipids and
thyroid hormones.
The study was performed on 125 persons, among them 73 had
thyroid dysfunction were accepted in the study as patients group and
52 subjects with normal thyroid function and no history of chronic
diseases were taken as control group. Then the patient group
subdivided into hypothyroidism and hyperthyroidism groups on the
bases of clinical examination and laboratory investigation for thyroid
hormones. Serum total cholesterol (TC), High density lipoprotein
cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), very
low density lipoprotein (VLDL), and Triglyceride (TG) were assessed in
all groups.
Our study indicate that there is a highly significant increase
(p<0.0001) in the levels of TC, LDL, VLDL, and TG whereas HDL
levels was found significantly decreased in hypothyroidism cases
compared to hyperthyroidism and control subjects. Hyperthyroidism
patients present highly significant decrease in serum level of TC, TG,
LDL, and VLDL (p?0.0001) compared to control subjects. There is
significantly increase in the activity of HDL in hyperthyroidism
patients when compared with control subjects (p?0.001). I conclude
that any increase in the levels of lipid fractions LDL, TC, VLDL and
TG with a decrease in HDL levels may be contributory factor to the high risk of atherosclerosis induced coronary heart disease observed in
hypothyroidism patients. | | Keywords : | | | Hypothyroidism, Hyperthyroidism, thyroid hormone,
lipid profile, atherosclerosis |
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