| Article Details : |
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| | | Article Name : | | | The fate of ovarian cancer in an era of
immunotherapy | | Author Name : | | | DOOMAH YUSSRIYA HANAA, YING XIAO YAN1 | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Ovarian cancer is the leading cause of death from gynecologic
malignancies with an overall 5-year survival rate of <45%. Most
patients are diagnosed at stage III/IV due to the lack of adequate
screening biomarkers and the paucity of early symptoms. The gold
standard of treatment is aggressive debulking surgery, followed by
platinum-based chemotherapy. However, ovarian cancer has a high
recurrence rate. Recently, the emergence of immunotherapy has shown
promising results in the treatment of various cancers. This has led to
the exploration of possible immunotherapeutic options as a second-line
treatment for recurrent ovarian cancer. This review focuses on the
mechanisms of tumor evasion and the emerging immunotherapeutic
options that can improve clinical outcomes. | | Keywords : | | | ovarian neoplasms, immunotherapy, tumor escape,
chemotherapy
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