Article Details : |
| | Article Name : | | Assessment of Immunological Changes in Workers
Occupationally Exposed to Low Levels of Ionizing
Radiation | Author Name : | | Z. S. SAID
| Publisher : | | Bridge Center | Article URL : | | | Abstract : | | Long-term of low-dose ionizing radiation exposure may
produce adverse health effects. The immune system is recognized to be
extremely radiosensitive; consequently it is vulnerable to radiation.
The aim of this study is to investigate the effect of low levels of ionizing
radiation on immune responses in angiography workers chronically
exposed to ionizing radiation. The study population consists of 36
workers occupationally exposed to ionizing radiation; 18workers less
than a 5 years working period (group 1) and 18 workers more than a 5
years working period (group 2). The control group consists of
20subjects with no exposure to ionizing radiation. The concentrations
of immunoglobulins Ig A, M and G and cytokine production such as
tumor necrosis factor-? (TNF-?) and interferon-? (INF-?) were
determined in blood serum. The results revealed that in group 1, the
levels of IgA, IgM, IgG, TNF-? and IFN-? were slightly higher than the
control levels. In group 2, IgG was slightly higher, but IgM, TNF-?
and IFN-? were slightly lower than the control levels. The results
showed also that, in workers of group 2 (more than 5 years) the levels
of IgM, IgG, TNF-? and IFN-? were significantly lower than in
workers of group 1 (lower than 5 years). It is concluded that the
immune system may have an adaptation mechanism for coping with
occupational radiation exposure in workers of group 2.It is advised to
perform a periodic check-up on the immune functions in radiology
workers to detect any early changes in the immune system. | Keywords : | | Low-doses ionizing radiation, X-ray, TNF-?, INF-?,
Immunoglobulins, Occupational workers. |
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