European Academic Research ISSN 2286-4822
ISSN-L 2286-4822
Impact Factor: 3.4546 (UIF)
DRJI Value : 5.9 (B+)
Article Details :
Article Name :
Assessment of Immunological Changes in Workers Occupationally Exposed to Low Levels of Ionizing Radiation
Author Name :
Z. S. Said
Publisher :
Bridge Center
Article URL :
Abstract :
Long-term of low-dose ionizing radiation exposure may produce adverse health effects. The immune system is recognized to be extremely radiosensitive; consequently it is vulnerable to radiation. The aim of this study is to investigate the effect of low levels of ionizing radiation on immune responses in angiography workers chronically exposed to ionizing radiation. The study population consists of 36 workers occupationally exposed to ionizing radiation; 18workers less than a 5 years working period (group 1) and 18 workers more than a 5 years working period (group 2). The control group consists of 20subjects with no exposure to ionizing radiation. The concentrations of immunoglobulins Ig A, M and G and cytokine production such as tumor necrosis factor-a (TNF-a) and interferon-? (INF-?) were determined in blood serum. The results revealed that in group 1, the levels of IgA, IgM, IgG, TNF-a and IFN-? were slightly higher than the control levels. In group 2, IgG was slightly higher, but IgM, TNF-a and IFN-? were slightly lower than the control levels. The results showed also that, in workers of group 2 (more than 5 years) the levels of IgM, IgG, TNF-a and IFN-? were significantly lower than in workers of group 1 (lower than 5 years). It is concluded that the immune system may have an adaptation mechanism for coping with occupational radiation exposure in workers of group 2.It is advised to perform a periodic check-up on the immune functions in radiology workers to detect any early changes in the immune system.
Keywords :
Low-doses ionizing radiation, X-ray, TNF-a, INF-?, Immunoglobulins, Occupational workers.

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