| Article Details : |
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| | | Article Name : | | | Bone and Skin Tissue Engineering based on
Cytotoxicity Assays of PLLA Fibrous Mats
Synthesized via Centrifugal Spinning | | Author Name : | | | BÁRBARA ETRURI CIOCCA1,NAHIEH TOSCANO MIRANDA, GUINEA BRASIL CAMARGO CARDOSO
ANA AMÉLIA RODRIGUES
ANA FLÁVIA PATTARO, ANDRÉ LUIZ JARDINI MUNHOZ
RUBENS MACIEL FILHO | | Publisher : | | | Bridge Center | | Article URL : |  | | | Abstract : | | | Poly (L-lactic acid) (PLLA) is a biocompatible polymer widely
used in a range of applications and is already recognized in the
medical field as a biomaterial. The main objective of the present work
was the production of polymeric mats to be applied in tissue
engineering. PLLA mats were produced through the centrifugal
spinning process. Scanning electron microscopy (SEM) analyzed the fibers diameter, disposition, and morphology. The fibers presented a
uniform and constant diameter (16.24 µm), being arranged randomly.
Thermogravimetric analysis (TGA) technique verified variation of
mass loss with temperature, in which the material degradation
temperature started at 205 °C. Differential scanning calorimetry (DSC)
determined phase transition temperatures. Fourier-transform infrared
spectroscopy (FT-IR) evaluated PLLA fibrous membrane chemical
groups. Cytotoxicity assays verified fibroblasts and osteoblasts
viabilities by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-
Diphenyltetrazolium Bromide), AlamarBlue®, and Live/Dead® for 24,
48, and 72 h. This work results demonstrated that PLLA mats have
great potential for tissue engineering applications in wound healing
and bone repairing, being a promising biomaterial with high
biocompatibility. | | Keywords : | | | PLLA; centrifugal spinning; tissue engineering;
biomaterial; biocompatibility. |
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